ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for
regulating leukocyte recruitment from circulation to sites of inflammation. However, in …

CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Specialized membrane domains are an important feature of almost all cells. In particular,
they are essential to tissues that have a highly organized cell cortex, such as the intestinal …

Cell-adhesion molecules, once believed to function primarily in tethering cells to
extracellular ligands, are now recognized as having broader functions in cellular signalling …

A fundamental property of many plasma-membrane proteins is their association with the
underlying cytoskeleton to determine cell shape, and to participate in adhesion, motility and …

The CD44 proteins form a ubiquitously expressed family of cell surface adhesion molecules
involved in cell-cell and cell-matrix interactions. The multiple protein isoforms are encoded …

Mucosal repair is a complex event that immediately follows acute injury induced by ischemia
and noxious luminal contents such as bile. In the small intestine, villous contraction is the …

Angiogenesis is required for normal development and occurs as a pathological step in a
variety of disease settings, such as cancer, ocular diseases, and ischemia. Recent studies …

Ezrin, radixin, and moesin (ERM) regulate cortical morphogenesis and cell adhesion by
connecting membrane adhesion receptors to the actin-based cytoskeleton. We have studied …

Hyaluronan is a very large polysaccharide that is found in extracellular matrices, at the cell
surface and inside cells. This review focuses on the functions of hyaluronan directly …