The therapeutic efficacy of whole tumor cell vaccines (TCVs) is modest, which has delayed
their translation into personalized immunotherapies in the clinic. Here, we develop a TCV …

The tyrosine kinase inhibitors (TKIs) have revolutionized the management of chronic
myeloid leukemia (CML) and BCR-ABL1 inhibitors form the mainstay of CML treatment …

One of the earliest methods used in the manufacture of stable and safe vaccines is the use
of chemical and physical treatments to produce inactivated forms of pathogens. Although …

Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has
become a standard treatment for patients with certain aggressive B cell malignancies and …

The COVID-19 pandemic has made clear the need for effective and rapid vaccine
development methods. Conventional inactivated virus vaccines, together with new …

We have recently reported that treatment of disseminated pancreatic cancer with an
attenuated Toxoplasma gondii uracil auxotroph vaccine promoted antitumor CD8+ T cell …

The introduction of protein tyrosine kinase inhibitors (TKI s) in 1998 transformed the
management of chronic myeloid leukemia (CML), leading to significantly reduced mortality …

The ability to target myeloid malignancies using immunotherapy through means other than
allogeneic transplantation depends on the capability to target leukemic clones while sparing …

Dendritic cells (DCs) are bone-marrow-derived immune cells accounted for a key role in
cancer vaccination as potent antigen-presenting cells within the immune system. Cancer …

Insights concerning leukemic pathophysiology have been acquired in various animal
models and further efforts to understand the mechanisms underlying leukemic treatment …