Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations
In recent decades, bacteriocins have received substantial attention as antimicrobial
compounds. Although bacteriocins have been predominantly exploited as food …
compounds. Although bacteriocins have been predominantly exploited as food …
Engineered human blood–brain barrier microfluidic model for vascular permeability analyses
The blood–brain barrier (BBB) greatly restricts the entry of biological and engineered
therapeutic molecules into the brain. Due to challenges in translating results from animal …
therapeutic molecules into the brain. Due to challenges in translating results from animal …
Probiotics, prebiotics, and phytogenic substances for optimizing gut health in poultry
The gut microbiota has been designated as a hidden metabolic 'organ'because of its
enormous impact on host metabolism, physiology, nutrition, and immune function. The …
enormous impact on host metabolism, physiology, nutrition, and immune function. The …
Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …
Pluripotent stem cell-derived epithelium misidentified as brain microvascular endothelium requires ETS factors to acquire vascular fate
Cells derived from pluripotent sources in vitro must resemble those found in vivo as closely
as possible at both transcriptional and functional levels in order to be a useful tool for …
as possible at both transcriptional and functional levels in order to be a useful tool for …
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
Chitosan nanoparticles at the biological interface: implications for drug delivery
N Aibani, R Rai, P Patel, G Cuddihy, EK Wasan - Pharmaceutics, 2021 - mdpi.com
The unique properties of chitosan make it a useful choice for various nanoparticulate drug
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …
delivery applications. Although chitosan is biocompatible and enables cellular uptake, its …
Neuronal regulation of the blood–brain barrier and neurovascular coupling
L Kaplan, BW Chow, C Gu - Nature Reviews Neuroscience, 2020 - nature.com
To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …