Breast cancer is the most commonly diagnosed cancer and second-leading cause of cancer
deaths in women. Breast cancer stem cells (BCSCs) promote metastasis and therapeutic …

Despite enormous progress in the treatment of many malignancies, the development of
cancer resistance is still an important reason for cancer chemotherapy failure. Increasing …

Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a
moiety of great significance. It forms an important intermediate in many industrial and …

Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

Currently, there is a renewed interest in common dietaries and plant-based traditional
medicines for the prevention and treatment of cancer. In the search for potential anticancer …

Highlights•The higher investment on HTS did not result in enhanced productivity of new
drugs.•FBDD emerged as an attractive strategy in drug discovery over the past two …

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4, 5, 6, 7-
tetrahydrobenzo [b] thiophene-3-carboxylate 1. An interesting cyclization was obtained …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

STAT (Signal Transducers and Activators of Transcription) is a cellular signal transcription
factor involved in the regulation of many cellular activities, such as cell differentiation …

Innate lymphoid cells (ILCs) are a family of immune cells that selectively accumulate in
mucosal tissues serving as sentinels at the vanguard of host protective immunity. However …