Introduction: Metformin is currently first line therapy for type 2 diabetes (T2D). The
mechanism of action of metformin involves activation of AMP-activated protein kinase …

Metformin is a hypoglycemic drug widely used in the treatment of type 2 diabetes. It has
been proven to have analgesic and neuroprotective effects. Metformin can reverse pain in …

Aging is an important risk factor for kidney injury. Energy homeostasis plays a key role in
retarding aging, and mitochondria are responsible for energy production. In the kidney, renal …

Patients with systemic lupus erythematosus (SLE) often suffer from chronic pain. Little is
known about the peripheral mechanisms underlying the genesis of chronic pain induced by …

Patients with systemic lupus erythematosus (SLE) frequently experience chronic pain due to
the limited effectiveness and safety profiles of current analgesics. Understanding the …

Background Increasing evidence has shown that the occurrence and development of
various human diseases are closely related to the gut microbiota. We compared the gut …

The understanding of pain pathophysiology is continuously evolving. Identifying underlying
cellular and subcellular pathways helps create opportunities for targeted therapies that may …

Background and objectives Intervertebral disc herniation is one of the common causes of
low back pain. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) activator …

BACKGROUND: Disk herniation is a primary cause of radicular back pain. The purpose of
this study was to evaluate the antiallodynic effective dose in 50% of the sample (ED 50) and …

摘要二甲双胍是一种广泛用于治疗2 型糖尿病的降糖药物. 它已被证明具有镇痛和神经保护作用.
二甲双胍可以逆转啮齿类动物的疼痛, 如糖尿病性神经痛, 化疗药物引起的神经性疼痛 …