Effects of exercise and aging on skeletal muscle

G Distefano, BH Goodpaster - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
A substantial loss of muscle mass and strength (sarcopenia), a decreased regenerative
capacity, and a compromised physical performance are hallmarks of aging skeletal muscle …

Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review

WK Mitchell, J Williams, P Atherton, M Larvin… - Frontiers in …, 2012 - frontiersin.org
Changing demographics make it ever more important to understand the modifiable risk
factors for disability and loss of independence with advancing age. For more than two …

Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome

Y Zhang, S Zhang, B Li, Y Luo, Y Gong… - Cardiovascular …, 2022 - academic.oup.com
Aims Ageing is the most significant contributor to the increasing prevalence of atrial
fibrillation (AF). The gut microbiota dysbiosis is involved in age-related diseases. However …

[PDF][PDF] Leucocytes, cytokines and satellite cells: what role do they play in muscle damage and regeneration following eccentric exercise?

G Paulsen, U Ramer Mikkelsen, T Raastad… - Exercise immunology …, 2012 - paulogentil.com
Exercise-induced muscle damage is an important topic in exercise physiology. However,
several aspects of our understanding of how muscles respond to highly stressful exercise …

Aging of the musculoskeletal system: How the loss of estrogen impacts muscle strength

BC Collins, EK Laakkonen, DA Lowe - Bone, 2019 - Elsevier
Skeletal muscle weakness occurs with aging and in females this is compounded by the loss
of estrogen with ovarian failure. Estrogen deficiency mediates decrements in muscle …

Lengthening our perspective: morphological, cellular, and molecular responses to eccentric exercise

RD Hyldahl, MJ Hubal - Muscle & nerve, 2014 - Wiley Online Library
The response of skeletal muscle to unaccustomed eccentric exercise has been studied
widely, yet it is incompletely understood. This review is intended to provide an up‐to‐date …

Associations between sedentary behaviour and body composition, muscle function and sarcopenia in community-dwelling older adults

J Gianoudis, CA Bailey, RM Daly - Osteoporosis international, 2015 - Springer
While previous studies have reported detrimental associations of sedentary behaviours with
cardiometabolic disorders and mortality, in this study, we report that higher levels of sitting …

Chronic low-grade inflammation and age-related sarcopenia

I Beyer, T Mets, I Bautmans - … in Clinical Nutrition & Metabolic Care, 2012 - journals.lww.com
Associations between CLIP and sarcopenia are observed quite consistently and underlying
mechanisms become apparent. Exercise remains the mainstay intervention to lower CLIP …

Interplay between ROS and antioxidants during ischemia-reperfusion injuries in cardiac and skeletal muscle

T Zhou, ER Prather, DE Garrison, L Zuo - International journal of …, 2018 - mdpi.com
Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major
clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR …

The role of innate and adaptive immune cells in skeletal muscle regeneration

N Ziemkiewicz, G Hilliard, NA Pullen… - International journal of …, 2021 - mdpi.com
Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide
variety of innate and adaptive immune cells orchestrate the complex process of muscle …