Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

ABSTRACT A simple post-transcriptional modification of tRNA, deamination of adenosine to
inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble …

MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …

Interactions of analytes with metal surfaces in high-performance liquid chromatography
(HPLC) instruments and columns have been reported to cause deleterious effects ranging …

Conspectus Nucleophilic addition of bisulfite to pyrimidine bases has been known for a half
century, and the reaction has been in use for at least a quarter of a century for identifying 5 …

Antimicrobial resistance develops as a major problem in infectious diseases treatment.
While antibiotic resistance mechanisms are usually studied using lethal antibiotic doses …

Ribosomal RNA modifications are introduced by specific enzymes during ribosome
assembly in bacteria. Deletion of individual modification enzymes has a minor effect on …

Immunoglobulin family and carbohydrate vascular addressins encoded by Madcam1 and
St6gal1 control lymphocyte homing into intestinal tissues, regulating immunity and …

Liquid chromatography tandem mass spectrometry (LC-MS/MS) has proven to be a powerful
analytical tool for the characterization of modified ribonucleic acids (RNAs). The typical …

The structure, stability, and function of various coding and noncoding RNAs are influenced
by chemical modifications. Pseudouridine (Ψ) is one of the most abundant post …