Digging deeper through glucose metabolism and its regulators in cancer and metastasis

M Ghanavat, M Shahrouzian, ZD Zayeri… - Life sciences, 2021 - Elsevier
Glucose metabolism enzymes and transporters play major role in cancer development and
metastasis. In this study, we discuss glucose metabolism, transporters, receptors, hormones …

[HTML][HTML] Dietary approaches for exploiting metabolic vulnerabilities in cancer

O Menyhárt, B Győrffy - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Renewed interest in tumor metabolism sparked an enthusiasm for dietary interventions to
prevent and treat cancer. Changes in diet impact circulating nutrient levels in the plasma …

Role of tyrosine phosphorylation in modulating cancer cell metabolism

ML Taddei, E Pardella, E Pranzini, G Raugei… - Biochimica et Biophysica …, 2020 - Elsevier
In mammalian cells, tyrosine phosphorylation is one of the main mechanisms responsible for
regulating signal transduction pathways and key cellular functions. Moreover, recent studies …

Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer

Y Wang, L Zhao, Y Geng, H Yuan, C Hou… - Acta Pharmacologica …, 2023 - nature.com
Aspirin as a chemopreventive agent is able to restrict the tumor growth. Phosphoglycerate
mutase 1 (PGAM1) is a key enzyme of glycolysis, playing an important role in the …

6‐Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance

I Sarfraz, A Rasul, G Hussain, MA Shah, AF Zahoor… - …, 2020 - Wiley Online Library
Reprogrammed metabolism is key biochemical characteristic of malignant cells, which
represents one of the emerging hallmarks of cancer. Currently, there is rising contemplation …

Role of glycolytic and glutamine metabolism reprogramming on the proliferation, invasion, and apoptosis resistance through modulation of signaling pathways in …

C Trejo-Solis, D Silva-Adaya, N Serrano-García… - International Journal of …, 2023 - mdpi.com
Simple Summary Metabolic reprogramming in glioblastoma is a hallmark of malignancy.
Metabolic enzymes and metabolites participate in energetic metabolism and function as …

PGAM1 regulation of ASS1 contributes to the progression of breast cancer through the cAMP/AMPK/CEBPB pathway

M Liu, R Li, M Wang, T Liu, Q Zhou, D Zhang… - Molecular …, 2022 - Wiley Online Library
Phosphoglycerate mutase 1 (PGAM1) is a crucial glycolytic enzyme, and its expression
status has been confirmed to be associated with tumor progression and metastasis …

Candida pathogenicity and interplay with the immune system

N Valand, UV Girija - Microbial Pathogenesis: Infection and Immunity, 2021 - Springer
Candida species are opportunistic fungal pathogens that are part of the normal skin and
mucosal microflora. Overgrowth of Candida can cause infections such as thrush or life …

[HTML][HTML] Mangifera indica extracts as novel PKM2 inhibitors for treatment of triple negative breast cancer

A Rasul, A Riaz, W Wei, I Sarfraz… - BioMed Research …, 2021 - pmc.ncbi.nlm.nih.gov
Pyruvate kinase (PK), a key enzyme that determines glycolytic activity, has been known to
support the metabolic phenotype of tumor cells, and specific pyruvate kinase isoform M2 …

GLUT1 biological function and inhibition: research advances

S Cao, Y Chen, Y Ren, Y Feng… - Future Medicinal Chemistry, 2021 - Taylor & Francis
The GLUT is a key regulator of glucose metabolism and is widely expressed on the surface
of most cells of the body. GLUT provides a variety of nutrients for the growth, proliferation …