Cigarette smoking is a major risk factor for gastrointestinal disorders, such as peptic ulcer,
Crohn's disease (CD), and several cancers. The mechanisms proposed to explain the role of …

Tobacco use is the single most important preventable health risk in the developed world,
and an important cause of premature death worldwide. Smoking causes a wide range of …

BACKGROUND AND AIMS: We sought to assess the evolution of Crohn's disease behavior
in an American population-based cohort. METHODS: Medical records of all Olmsted County …

Current smoking protects against ulcerative colitis and, after onset of the disease, improves
its course, decreasing the need for colectomy. However, smoking increases the risk of …

Inflammatory bowel diseases have a natural course characterized by alternating periods of
remission and relapse. Disease flares occur in a random way and are currently …

Despite improved immunosuppressive therapy, surgical resection is still often required for
uncontrolled inflammatory disease and the stenosing and perforating complications of …

Although in Crohn's disease post-operative recurrence is common, the determinants of
disease recurrence remain speculative. The aim of this study was to examine factors …

Until recently, the standard of care (SOC) for patients with chronic hepatitis C virus (HCV)
infection has consisted of a combination of pegylated interferon-N1 plus ribavirin …

Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract at any
point from the mouth to the rectum. Patients may experience diarrhea, abdominal pain, fever …

Smoking is associated with an increased risk of cancer, pulmonary and cardiovascular
diseases, but the precise mechanisms by which such risk is mediated remain poorly …