Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …

Calcium modulates many neural processes, including synaptic plasticity and apoptosis.
Dysregulation of intracellular calcium signalling has been implicated in the pathogenesis of …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Amyloid-β precursor protein (APP), a widely expressed cell-surface protein, is cleaved in the
transmembrane region by γ-secretase. γ-Cleavage of APP produces the extracellular …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

The ErbB-4 receptor protein-tyrosine kinase is proteolytically processed by membrane
proteases in response to the ligand or 12-O-tetradecanoylphorbol-13-acetate stimulation …

Physiological processing of the β-amyloid precursor protein (APP) generates amyloid β-
protein, which can assemble into oligomers that mediate synaptic failure in Alzheimer's …

▪ Abstract The low-density–lipoprotein (LDL) receptor family is an evolutionarily ancient
gene family of structurally closely related cell-surface receptors. Members of the family are …

The hallmark neuropathology of Huntington's disease (HD) is due to elongation of a
polyglutamine segment in huntingtin, a novel∼ 350 kDa protein of unknown function. We …