Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Coronaviruses are pathogens with a serious impact on human and animal health. They
mostly cause enteric or respiratory disease, which can be severe and life threatening, eg, in …

From yeast to mammals, autophagy is an important mechanism for sustaining cellular
homeostasis through facilitating the degradation and recycling of aged and cytotoxic …

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is the most recent example of
an emergent coronavirus that poses a significant threat to human health. Virus-host …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex
post-translational modulation of the Atg (autophagy-related) proteins adds additional entry …

Positive-strand RNA viruses replicate in close association with rearranged intracellular
membranes. For hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus …

On-going pandemic pneumonia outbreak COVID-19 has raised an urgent public health
issue worldwide impacting millions of people with a continuous increase in both morbidity …

Cancer cells encounter numerous stresses that pose a threat to their survival. Tumor
microenviroment stresses that perturb protein homeostasis can produce endoplasmic …

Some nascent proteins that fold within the endoplasmic reticulum (ER) never reach their
native state. Misfolded proteins are removed from the folding machinery, dislocated from the …