CTGF is a multifunctional protein and plays different roles in different cells and under
different conditions. Pamrevlumab, a monoclonal antibody against CTGF, is an FDA …

Articular cartilage injury and repair is an issue of growing importance. Although common,
defects of articular cartilage present a unique clinical challenge due to its poor self-healing …

Dedifferentiation of chondrocyte greatly restricts its function and application, however, it is
poorly understood except a small number of canonical markers. The non-cell-adhesive …

Three dimensional hydrogels are a promising vehicle for delivery of adult human bone-
marrow derived mesenchymal stem cells (hMSCs) for cartilage tissue engineering. One of …

Osteoarthritis (OA) is a debilitating joint disease characterized by articular cartilage
degradation, inflammation and pain. An extensive range of in vivo and in vitro studies …

Osteoarthritis (OA) is one of the most common types of arthritis in the elderly people. It has
been known that chondrocyte apoptosis occurs in OA cartilage; however, the detailed …

Cartilage tissue engineering strategies that use in situ forming degradable hydrogels for
mesenchymal stem cell (MSC) delivery are promising for treating chondral defects …

Chondrodysplasias are a group of genetic disorders that affect the development and growth
of cartilage. These disorders can result in extreme short stature, craniofacial defects, joint …

Objective: Protein kinase-like endoplasmic reticulum kinase (PERK) and protein kinase R
(PKR) are implicated in endoplasmic reticulum stress-induced arthritis and pro-inflammatory …

Objective The aim of this study was to evaluate the effects of different concentrations of
connective tissue growth factor (CTGF) on human periodontal ligament fibroblasts (HPLFs) …