DNA methylation and chromatin modifiers in colorectal cancer
V Vymetalkova, P Vodicka, S Vodenkova… - Molecular aspects of …, 2019 - Elsevier
Colorectal carcinogenesis is a multistep process involving the accumulation of genetic
alterations over time that ultimately leads to disease progression and metastasis. Binding of …
alterations over time that ultimately leads to disease progression and metastasis. Binding of …
Therapeutic potential of nicotinamide adenine dinucleotide (NAD)
M Arenas-Jal, JM Suñé-Negre… - European Journal of …, 2020 - Elsevier
Nicotinamide adenine nucleotide (NAD) is a small ubiquitous hydrophilic cofactor that
participates in several aspects of cellular metabolism. As a coenzyme it has an essential role …
participates in several aspects of cellular metabolism. As a coenzyme it has an essential role …
Sirtuin 2 isoform 1 enhances hepatitis B virus RNA transcription and DNA synthesis through the AKT/GSK-3β/β-catenin signaling pathway
ZZ Piracha, H Kwon, U Saeed, J Kim, J Jung… - Journal of …, 2018 - Am Soc Microbiol
ABSTRACT Sirtuin 2 (Sirt2), a NAD+-dependent protein deacetylase, is overexpressed in
many hepatocellular carcinomas (HCCs) and can deacetylate many proteins, including …
many hepatocellular carcinomas (HCCs) and can deacetylate many proteins, including …
SIRT7 exhibits oncogenic potential in human ovarian cancer cells
HL Wang, RQ Lu, SH Xie, H Zheng… - Asian Pacific Journal …, 2015 - koreascience.kr
Background: Sirtuin7 (SIRT7) is a type of nicotinamide adenine dinucleotide oxidized form
(NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is …
(NAD+)-dependent deacetylase and the least understood member of the sirtuins family; it is …
An alternatively spliced sirtuin 2 isoform 5 inhibits hepatitis B virus replication from cccDNA by repressing epigenetic modifications made by histone lysine …
ZZ Piracha, U Saeed, J Kim, H Kwon… - Journal of …, 2020 - Am Soc Microbiol
ABSTRACT Sirtuin 2 (Sirt2), an NAD+-dependent protein deacetylase, deacetylates tubulin,
AKT, and other proteins. Previously, we showed that Sirt2 isoform 1 (Sirt2. 1) increased …
AKT, and other proteins. Previously, we showed that Sirt2 isoform 1 (Sirt2. 1) increased …
Kaempferol and Apigenin suppresses the stemness properties of TNBC cells by modulating Sirtuins
Sirtuins (SIRTs) overexpression serves as a potential therapeutic target for TNBC because it
is associated with bioactivities of cancer stem cells (CSCs), resistance to chemotherapy, and …
is associated with bioactivities of cancer stem cells (CSCs), resistance to chemotherapy, and …
Sirtuin 1-chromatin-binding dynamics points to a common mechanism regulating inflammatory targets in SIV infection and in the aging brain
N Bortell, L Basova, JA Najera, B Morsey… - Journal of Neuroimmune …, 2018 - Springer
Microglia and macrophages are the main non-neuronal subsets of myeloid origin in the
brain, and are critical regulators in neurodegenerative disorders, where inflammation is a …
brain, and are critical regulators in neurodegenerative disorders, where inflammation is a …
Bioluminescence assay of lysine deacylase sirtuin activity
AN Van Scoyk, O Antelope, DE Ayer, RT Peterson… - Chemistry & Biology, 2024 - cell.com
Lysine acylation can direct protein function, localization, and interactions. Sirtuins deacylate
lysine toward maintaining cellular homeostasis, and their aberrant expression contributes to …
lysine toward maintaining cellular homeostasis, and their aberrant expression contributes to …