Background Peripheral blood monocyte counts have been associated with poor outcomes in
interstitial lung disease (ILD). However, studies are limited by variable biomarker thresholds …

Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a severe
manifestation of CTD that leads to significant morbidity and mortality. Clinically, ILD can …

Breast cancer is a prominent cause of cancer diagnosis and death in women globally, with
over 90% of deaths being attributed to complications that arise from metastasis. One of the …

Crystalline silica (CS) particles are ubiquitous in the environment, especially in occupational
conditions, and exposure to respirable CS causes silicosis. The initial response to CS is …

Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease (ILD) that affects
lung mechanical functions and gas exchange. IPF is caused by increased fibroblast activity …

IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to
respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled …

The interactions between immune cells and epithelial cells influence the progression of
many respiratory diseases, such as chronic obstructive pulmonary disease (COPD). In vitro …

Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disorder that is characterized by
the abnormal accumulation of surfactant within the alveoli. Alveolar macrophages (AMs) …

Chronic respiratory diseases and infections are among the largest contributors to death
globally, many of which still have no cure, including chronic obstructive pulmonary disorder …

Background Lung adenocarcinoma (LUAD) is a prevalent subtype of lung cancer associated
with high mortality rates. We aimed to utilize single-cell multiomics analysis to identify the …