Summary Alpha-1 antitrypsin deficiency (AATD) arises from mutations in the SERPINA1
gene encoding alpha-1 antitrypsin (AAT) that lead to AAT retention in the endoplasmic …

Chronic obstructive pulmonary disease (COPD) is a debilitating heterogeneous disease
characterised by unregulated proteolytic destruction of lung tissue mediated via a protease …

Human breath contains many volatile metabolites. However, few breath tests are currently
used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we …

Appropriate activation of coagulation requires a balance between procoagulant and
anticoagulant proteins in blood. Loss in this balance leads to hemorrhage and thrombosis. A …

Emerging evidence suggests that adverse early life events can affect long-term health
trajectories throughout life. Preterm birth, in particular, is a significant early life event that …

The emerging field of regenerative cell therapy is still limited by the few cell types that can
reliably be differentiated from pluripotent stem cells and by the immune hurdle of …

COPD, characterized by long-term poorly irreversible airway limitation and persistent
respiratory symptoms, has resulted in enormous challenges to human health worldwide …

Protein supplementation therapy using in vitro-transcribed (IVT) mRNA for genetic diseases
contains huge potential as a new class of therapy. From the early ages of synthetic mRNA …

SARS-CoV-2 was first reported from China. Within three months, it evolved to 10 additional
subtypes. Two evolved subtypes (A2 and A2a) carry a non-synonymous Spike protein …

The respiratory system acts as both the primary site of gas exchange and an important
sensor and barrier to the external environment. The increase in incidences of respiratory …