The global burden of early life adversity (ELA) is profound. The World Health Organization
has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to …

Adverse experiences in early life can shape neuronal structures and synaptic function in
multiple brain regions, leading to deficits of distinct cognitive functions later in life. Focusing …

Trauma and chronic stress exposure are the strongest predictors of lifetime neuropsychiatric
disease presentation. These disorders often have significant sex biases, with females …

Background Patterns of sensory inputs early in life play an integral role in shaping the
maturation of neural circuits, including those implicated in emotion and cognition. In both …

Exposure to adversities during early life stages (early life adversities-ELA), ranging from
pregnancy to adolescence, represents a major risk factor for the vulnerability to mental …

High unpredictability has emerged as a dimension of early-life adversity that may contribute
to a host of deleterious consequences later in life. Early-life unpredictability affects …

Early caregiving adversity (ECA) is associated with social behavior deficits and later
development of psychopathology. However, the infant neural substrates of ECA are poorly …

Abstract Background The nucleus accumbens (NAc) mediates reward learning and
motivation. Despite an abundance of neuropeptides, peptidergic neurotransmission from the …

The basolateral amygdala (BLA) is reliably activated by psychological stress and
hyperactive in conditions of pathological stress or trauma; however, subsets of BLA neurons …

Adverse early-life experiences (ELA) affect a majority of the world's children. Whereas the
enduring impact of ELA on cognitive and emotional health is established, there are no tools …