Objective Antibiotics change the composition of the intestinal microbiota. The magnitude of
the effect of antibiotics on the microbiota and whether the effects are short-term or persist …

The gut microbiome is now considered an organ unto itself and plays an important role in
health maintenance and recovery from critical illness. The commensal organisms …

Low serum albumin levels are very common in critically ill patients, with reported incidences
as high as 40–50%. This condition appears to be associated with alterations in the degree of …

Controversy reigns as to how protein binding changes alter the time course of unbound drug
concentrations in patients. Given that the unbound concentration is responsible for drug …

Antibiotics have been the most important risk factor for Clostridium difficile infection (CDI).
However, only data from non-randomised studies have been reviewed. We sought to …

By targeting essential cellular processes, antibiotics provoke metabolic perturbations and
induce stress responses and genetic variation in bacteria. Here we review current …

Antimicrobial agents are the most valuable means available for treating bacterial infections.
However, the administration of therapeutic doses of antimicrobial agents to patients is a …

Objectives First-line treatment options for Clostridium difficile infection (CDI) are limited.
NVB302 is a novel type B lantibiotic under evaluation for the treatment of CDI. We compared …

ABSTRACT Extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL
E. coli) strains are of major concern because few antibiotics remain active against these …

A better understanding of the impact of antibiotics on bacteria is required to increase the
efficiency of antibiotic treatments and to slow the emergence of resistance. Using …