The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

The prevalence of cardiovascular and metabolic disease coupled with kidney dysfunction is
increasing worldwide. This triad of disorders is associated with considerable morbidity and …

Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

Aging is a natural process, which plays a critical role in the pathogenesis of a variety of
diseases, ie, aging-related diseases, such as diabetes, osteoarthritis, Alzheimer disease …

Background: Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. Phenotyping patients into pathophysiologically homogeneous groups may …

This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic
signaling molecule involved in cardiovascular and metabolic regulation. More recently, an …

Research in the last decade has substantially advanced our understanding of the
pathophysiology of heart failure with preserved ejection fraction (HFpEF). However …

Background: Right ventricular (RV) adaptation to acute and chronic pulmonary hypertensive
syndromes is a significant determinant of short-and long-term outcomes. Although …