Epidemiological data indicate that more than 50% of patients with newly-diagnosed rectal
cancer are older than 70 years, with rising numbers expected over the next decades …

Introduction Total mesorectal excision (TME) is the standard-of-care in early, clinical stage
(cT2-3 N0 M0) rectal cancer. Local excision (LE) may be an alternative after adequate …

Purpose As the population ages, the incidence of rectal cancer among elderly patients is
rising. Due to the risk of perioperative morbidity and mortality, alternative nonoperative …

Radio- or Chemotherapy Dose Escalation for Organ Preservation in Rectal Cancer? Radio- or
Chemotherapy Dose Escalation for Organ Preservation in Rectal Cancer? J Clin Oncol. 2023 …

With the establishment of total mesorectal excision for the treatment of rectal cancer, local
recurrence rates have significantly decreased. The addition of preoperative external beam …

With increased therapeutic options in rectal cancer, a central question has become how to
tailor therapy to patient preferences to avoid both over and under treatment. Total …

Simple Summary With the introduction of better-quality imaging for tumor visualization and
treatment planning, a new conformed radiation treatment was introduced with high-dose …

We thank Kazi et al, 1 Sutcuoglu et al, 2 and Socha et al3 for their interest in the following
article. 4 The organ preservation approach for locally advanced rectal cancer is received …