Vaccine-induced immunity is expected to target the native antigens expressed by the
pathogens. Therefore, it is highly important to generate vaccine antigens that are …

Found in virtually every organism, glycans are essential molecules that play important roles
in almost every aspect of biology. The composition of glycome, the repertoire of glycans in …

High-parameter single-cell phenotyping has enabled in-depth classification and
interrogation of immune cells, but to date has not allowed for glycan characterization. Here …

Glycan–lectin interactions play an essential role in different cellular processes. One of their
main functions is involvement in the immune response to pathogens or inflammation …

Glycosylation is ubiquitous and often dysregulated in disease. However, the regulation and
functional significance of various types of glycosylation at cellular levels is hard to unravel …

Highlights•Pathogens alter host glycosylation through a variety of mechanisms.•During
infection, host immunity is directly modulated by changes in the host glycome.•Infection …

Background Carbohydrate–lectin interactions are extremely specific as the lectin is capable
of recognising monomeric and oligomeric sugars in a reversible manner. It has been known …

Glycosylation of viral envelope proteins is important for infectivity and immune evasion. The
SARS-CoV-2 spike protein is heavily glycosylated and host-derived glycan modifications …

Glycans play critical roles in the host–pathogen interactions leading to infection. However,
we still understand very little about the dynamic nature of glycosylation in response to …

Glycosylation is the most prominent modification important for vaccines and its specific
pattern depends on several factors that need to be considered when developing a new …