Hypertension-related risk for dementia: A summary review with future directions
AM Daugherty - Seminars in Cell & Developmental Biology, 2021 - Elsevier
Chronic hypertension, or high blood pressure, is the most prevalent vascular risk factor that
accelerates cognitive aging and increases risk for Alzheimer's disease and related …
accelerates cognitive aging and increases risk for Alzheimer's disease and related …
[HTML][HTML] Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging
Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …
GLP-1 programs the neurovascular landscape
B Chen, X Yu, C Horvath-Diano, MJ Ortuño… - Cell Metabolism, 2024 - cell.com
Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an
environment of overnutrition. This transformative setting has led to persistent health issues …
environment of overnutrition. This transformative setting has led to persistent health issues …
Hypertensive adults exhibit lower myelin content: a multicomponent relaxometry and diffusion magnetic resonance imaging study
BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination.
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 …
[HTML][HTML] Nonlinear associations of neurite density and myelin content with age revealed using multicomponent diffusion and relaxometry magnetic resonance imaging
Most magnetic resonance imaging (MRI) studies investigating the relationship between
regional brain myelination or axonal density and aging have relied upon nonspecific …
regional brain myelination or axonal density and aging have relied upon nonspecific …
Lower myelin content is associated with more rapid cognitive decline among cognitively unimpaired individuals
Introduction The influence of myelination on longitudinal changes in cognitive performance
remains unclear. Methods For each participant (N= 123), longitudinal cognitive scores were …
remains unclear. Methods For each participant (N= 123), longitudinal cognitive scores were …
Evidence of association between obesity and lower cerebral myelin content in cognitively unimpaired adults
M Bouhrara, N Khattar, P Elango, SM Resnick… - International Journal of …, 2021 - nature.com
Background Myelin loss is a central feature of several neurodegenerative diseases,
including Alzheimer's disease (AD). In animal studies, a link has been established between …
including Alzheimer's disease (AD). In animal studies, a link has been established between …
Association of cerebral blood flow with longitudinal changes in cerebral microstructural integrity in the coronary artery risk development in young adults (CARDIA) …
Importance Decreased cerebral tissue integrity and cerebral blood flow (CBF) are features of
neurodegenerative diseases. Brain tissue maintenance is an energy-demanding process …
neurodegenerative diseases. Brain tissue maintenance is an energy-demanding process …
[HTML][HTML] Differential associations between apolipoprotein E alleles and cerebral myelin content in normative aging
Mounting evidence indicates that myelin breakdown may represent an early phenomenon in
neurodegeneration, including Alzheimer's disease (AD). Understanding the factors …
neurodegeneration, including Alzheimer's disease (AD). Understanding the factors …
[HTML][HTML] Maturation and degeneration of the human brainstem across the adult lifespan
Brainstem tissue microstructural properties change across the adult lifespan. However,
studies elucidating the biological processes that govern brainstem maturation and …
studies elucidating the biological processes that govern brainstem maturation and …