Metabolic regulation of kisspeptin—the link between energy balance and reproduction

VM Navarro - Nature reviews endocrinology, 2020 - nature.com
Hypothalamic kisspeptin neurons serve as the nodal regulatory centre of reproductive
function. These neurons are subjected to a plethora of regulatory factors that ultimately affect …

Kisspeptin/GPR54 system: what do we know about its role in human reproduction?

CM Trevisan, E Montagna, R De Oliveira… - Cellular Physiology and …, 2018 - karger.com
Kisspeptin is involved in the control of human reproduction bridging the gap between the
sex steroid levels and feedback mechanisms that control the gonadotropin releasing …

Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders

A Abbara, PC Eng, M Phylactou… - The Journal of …, 2020 - Am Soc Clin Investig
BACKGROUND Kisspeptin is a key regulator of hypothalamic gonadotropin-releasing
hormone (GnRH) neurons and is essential for reproductive health. A specific kisspeptin …

Kisspeptin/kisspeptin receptor system in the ovary

KL Hu, H Zhao, HM Chang, Y Yu, J Qiao - Frontiers in endocrinology, 2018 - frontiersin.org
Kisspeptins are a family of neuropeptides that are critical for initiating puberty and regulating
ovulation in sexually mature females via the central control of the hypothalamic–pituitary …

Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment

A Abbara, SA Clarke, WS Dhillo - Endocrine reviews, 2018 - academic.oup.com
Infertility affects one in six of the population and increasingly couples require treatment with
assisted reproductive techniques. In vitro fertilization (IVF) treatment is most commonly …

The emerging therapeutic potential of kisspeptin and neurokinin B

B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction

KL Hu, Z Chen, X Li, E Cai, H Yang, Y Chen… - Reproductive Biology …, 2022 - Springer
Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …

Treatments targeting neuroendocrine dysfunction in polycystic ovary syndrome (PCOS)

A Garg, B Patel, A Abbara, WS Dhillo - Clinical endocrinology, 2022 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of
reproductive age and is the leading cause of anovulatory subfertility. Increased …

Anti-Müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome

A Abbara, PC Eng, M Phylactou, SA Clarke… - Frontiers in …, 2019 - frontiersin.org
Introduction: Polycystic ovarian syndrome (PCOS) is a leading cause of female subfertility
worldwide, however due to the heterogeneity of the disorder, the criteria for diagnosis …

[HTML][HTML] Polycystic ovary syndrome: pathophysiology and therapeutic opportunities

J Dong, DA Rees - BMJ medicine, 2023 - ncbi.nlm.nih.gov
Polycystic ovary syndrome is characterised by excessive levels of androgens and ovulatory
dysfunction, and is a common endocrine disorder in women of reproductive age. Polycystic …