Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …

Abstract The epithelial Na+ channel (ENaC) transports Na+ across tight epithelia, including
the distal nephron. Different paradigms of ENaC regulation include extrinsic and intrinsic …

The beneficial effects of oxytocin on infarct size and functional recovery of the ischemic
reperfused heart are well documented. The mechanisms for this cardioprotection are not …

Acid‐sensing ion channels (ASICs) and the epithelial Na+ channel (ENaC) are both
members of the ENaC/degenerin family of amiloride‐sensitive Na+ channels. ASICs act as …

The Na-Cl cotransporter NCC is expressed in the distal convoluted tubule, activated by
phosphorylation, and has been implicated in renal NaCl and K+ homeostasis. The serum …

The kidney plays an essential role in blood pressure regulation by controlling short-term and
long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) …

Na-K-Cl cotransporter (NKCC2)-mediated sodium chloride reabsorption in the thick
ascending limb is stimulated by the antidiuretic hormone vasopressin. We investigate the …

WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as
molecular switches, eliciting coordinated effects on diverse ion transport pathways to …

In renal epithelia, vasopressin influences salt and water transport, chiefly via vasopressin V2
receptors (V2Rs) linked to adenylyl cyclase. A combination of vasopressin-induced effects …