Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

In addition to constituting the genetic material of an organism, DNA is a tracer for the
recognition of foreign pathogens and a trigger of the innate immune system. cGAS functions …

Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-
mediated recycling of organelles and protein aggregates, as well as the destruction of …

Obesity and type 2 diabetes mellitus (T2DM) are increasing in prevalence owing to
decreases in physical activity levels and a shift to diets that include addictive and/or high …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Necroptosis is a caspase-independent form of programmed cell death executed by the
receptor interacting protein kinase 1 (RIPK1)-RIPK3-mixed lineage kinase domain-like …

Ovarian cancer (OC) is one of the most common malignancies that causes death in women
and is a heterogeneous disease with complex molecular and genetic changes. Because of …

Background Uveal melanoma (UVM) is the most common intraocular malignancy and has a
poor prognosis. The clinical significance of necroptosis (NCPS) in UVM is unclear. Methods …