Neuron to oligodendrocyte precursor cell synapses: protagonists in oligodendrocyte development and myelination, and targets for therapeutics

DMS Moura, EJ Brennan, R Brock… - Frontiers in …, 2022 - frontiersin.org
The development of neuronal circuitry required for cognition, complex motor behaviors, and
sensory integration requires myelination. The role of glial cells such as astrocytes and …

d-Amino acids: new clinical pathways for brain diseases

IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …

Remyelination in multiple sclerosis: findings in the cuprizone model

H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

Peptide Stereochemistry Effects from pKa-Shift to Gold Nanoparticle Templating in a Supramolecular Hydrogel

S Adorinni, S Gentile, O Bellotto, S Kralj, E Parisi… - ACS …, 2024 - ACS Publications
The divergent supramolecular behavior of a series of tripeptide stereoisomers was
elucidated through spectroscopic, microscopic, crystallographic, and computational …

Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model

R Ciccone, C Franco, I Piccialli, F Boscia… - Scientific reports, 2019 - nature.com
Hyperexcitability and alterations in neuronal networks contribute to cognitive impairment in
Alzheimer's Disease (AD). Voltage-gated sodium channels (NaV), which are crucial for …

Novel treatment strategies targeting myelin and oligodendrocyte dysfunction in schizophrenia

D Gouvêa-Junqueira, ACB Falvella… - Frontiers in …, 2020 - frontiersin.org
Oligodendrocytes are the glial cells responsible for the formation of the myelin sheath
around axons. During neurodevelopment, oligodendrocytes undergo maturation and …

Roles of glial ion transporters in brain diseases

S Song, L Luo, B Sun, D Sun - Glia, 2020 - Wiley Online Library
Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and
cellular signal transduction under physiological conditions of the central nervous system …

Regulation and signaling of the GPR17 receptor in oligodendroglial cells

D Lecca, S Raffaele, MP Abbracchio, M Fumagalli - Glia, 2020 - Wiley Online Library
Remyelination, namely, the formation of new myelin sheaths around denuded axons,
counteracts axonal degeneration and restores neuronal function. Considerable advances …

[HTML][HTML] Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

N Nagase, Y Ikeda, A Tsuji, Y Kitagishi… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic
options for preventing its progression are insufficient. The number of patients with DN has …

Gut protective effect from D-methionine or butyric acid against dss and carrageenan-induced ulcerative colitis

Y Ikeda, S Matsuda - Molecules, 2023 - mdpi.com
Microbiome dysbiosis resulting in altered metabolite profiles may be associated with certain
diseases, including inflammatory bowel diseases (IBD), which are characterized by active …