Neuron to oligodendrocyte precursor cell synapses: protagonists in oligodendrocyte development and myelination, and targets for therapeutics
DMS Moura, EJ Brennan, R Brock… - Frontiers in …, 2022 - frontiersin.org
The development of neuronal circuitry required for cognition, complex motor behaviors, and
sensory integration requires myelination. The role of glial cells such as astrocytes and …
sensory integration requires myelination. The role of glial cells such as astrocytes and …
d-Amino acids: new clinical pathways for brain diseases
IN de Oliveira Souza, R Roychaudhuri… - Trends in Molecular …, 2023 - cell.com
Free d-amino acids (d-AAs) are emerging as a novel and important class of signaling
molecules in many organs, including the brain and endocrine systems. There has been …
molecules in many organs, including the brain and endocrine systems. There has been …
Remyelination in multiple sclerosis: findings in the cuprizone model
H Leo, M Kipp - International Journal of Molecular Sciences, 2022 - mdpi.com
Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …
Peptide Stereochemistry Effects from pKa-Shift to Gold Nanoparticle Templating in a Supramolecular Hydrogel
The divergent supramolecular behavior of a series of tripeptide stereoisomers was
elucidated through spectroscopic, microscopic, crystallographic, and computational …
elucidated through spectroscopic, microscopic, crystallographic, and computational …
Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer's Disease Mouse Model
Hyperexcitability and alterations in neuronal networks contribute to cognitive impairment in
Alzheimer's Disease (AD). Voltage-gated sodium channels (NaV), which are crucial for …
Alzheimer's Disease (AD). Voltage-gated sodium channels (NaV), which are crucial for …
Novel treatment strategies targeting myelin and oligodendrocyte dysfunction in schizophrenia
D Gouvêa-Junqueira, ACB Falvella… - Frontiers in …, 2020 - frontiersin.org
Oligodendrocytes are the glial cells responsible for the formation of the myelin sheath
around axons. During neurodevelopment, oligodendrocytes undergo maturation and …
around axons. During neurodevelopment, oligodendrocytes undergo maturation and …
Roles of glial ion transporters in brain diseases
Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and
cellular signal transduction under physiological conditions of the central nervous system …
cellular signal transduction under physiological conditions of the central nervous system …
Regulation and signaling of the GPR17 receptor in oligodendroglial cells
D Lecca, S Raffaele, MP Abbracchio, M Fumagalli - Glia, 2020 - Wiley Online Library
Remyelination, namely, the formation of new myelin sheaths around denuded axons,
counteracts axonal degeneration and restores neuronal function. Considerable advances …
counteracts axonal degeneration and restores neuronal function. Considerable advances …
[HTML][HTML] Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy
N Nagase, Y Ikeda, A Tsuji, Y Kitagishi… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic
options for preventing its progression are insufficient. The number of patients with DN has …
options for preventing its progression are insufficient. The number of patients with DN has …
Gut protective effect from D-methionine or butyric acid against dss and carrageenan-induced ulcerative colitis
Y Ikeda, S Matsuda - Molecules, 2023 - mdpi.com
Microbiome dysbiosis resulting in altered metabolite profiles may be associated with certain
diseases, including inflammatory bowel diseases (IBD), which are characterized by active …
diseases, including inflammatory bowel diseases (IBD), which are characterized by active …