The rapidly emerging field of computational pathology has demonstrated promise in
developing objective prognostic models from histology images. However, most prognostic …

Background Cuproptosis is a copper-dependent cell death mechanism that is associated
with tumor progression, prognosis, and immune response. However, the potential role of …

Over the last few decades, major efforts in cancer research and treatment have intensified.
Apart from standard chemotherapy approaches, immunotherapy has gained substantial …

In cancer research, RAS biology has been focused on only a handful of tumor types. While
RAS genes have long been suspected as common contributors to a wide spectrum of cancer …

Objective: We aimed to investigate the relationship between titin (TTN) gene mutations and
thyroid cancer (THCA) and to explore the feasibility of the TTN gene as a potential …

Background: Lung adenocarcinoma (LUAD) is a highly heterogeneous tumor with
substantial somatic mutations and genome instability, which are emerging hallmarks of …

Hepatocellular carcinoma (HCC) is one of the most common malignancies globally and the
second leading cause of cancer-related death. Low-density lipoprotein (LDL) receptor …

Background: Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and has a
poor prognosis. Disulfidptosis is a novel regulated cell death form characterized by aberrant …

Stomach adenocarcinoma (STAD) is one of the most common malignant tumors worldwide.
In this study, we attempted to construct a valid immune-associated gene prognostic index …

Motivation Genomic instability is a hallmark of cancer, leading to many somatic alterations.
Identifying which alterations have a system-wide impact is a challenging task. Nevertheless …