Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Aim It has been suggested that chronic hyperinsulinemia from insulin resistance is involved
in the etiology of endometrial cancer (EC). We performed a systematic review and meta …

Cancers in hormone-responsive tissues (eg, breast, ovary, endometrium, prostate) occur at
high incidence rates worldwide. However, their genetic basis remains poorly understood …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Background Lung cancer has high morbidity and mortality across the globe, and lung
adenocarcinoma (LUAD) is the most common histologic subtype. Disordered lipid …

The aim of the present study was to identify genomic alterations in Taiwanese endometrial
cancer patients. This information is vitally important in Taiwan, where endometrial cancer is …

Dysregulation of nucleotide-binding oligomerization domains 1 and 2 (NOD1 and NOD2)
has been implicated in the pathology of various inflammatory disorders, rendering them and …

A number of studies have reported on the unusual pharmacological behavior of type I
antiestrogens, such as tamoxifen. These agents display mixed agonist/antagonist activity in …

Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of
various human diseases, such as endometriosis and cancers arising from the breast and …

In situ estrogen biosynthesis is considered to play pivotal roles in the development and
progression of human endometrial carcinoma. However, the biological roles of androgen …