Alterations in protein ubiquitylation and hypoxia are commonly associated with cancer.
Ubiquitylation is carried out by three sequentially acting ubiquitylating enzymes and can be …

Alterations in protein ubiquitination and hypoxia-inducible factor (HIF) signaling both
contribute to tumorigenesis and tumor progression. Ubiquitination is a dynamic process that …

Simple Summary Previous clinical studies have suggested a relationship between
obstructive sleep apnea and some types of cancer. This relationship is very heterogeneous …

To date, 18 distinct receptor tyrosine kinases (RTKs) are reported to be trafficked from the
cell surface to the nucleus in response to ligand binding or heterologous agonist exposure …

Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …

Human genome harbors 55 receptor tyrosine kinases (RTK). At least half of the RTKs have
been reported to be cleaved by gamma-secretase-mediated regulated intramembrane …

Receptor tyrosine kinases (RTKs) have been demonstrated to signal via regulated
intramembrane proteolysis, in which ectodomain shedding and subsequent intramembrane …

Heregulins (HRGs) bind to the receptors HER3 or HER4, induce receptor dimerization, and
trigger downstream signaling that leads to tumor progression and resistance to targeted …

Introduction Hypoxia-inducible factor (HIF) mediates multiple intracellular processes that
drive cellular metabolism and induce proliferation. Dysregulated HIF expression is …

The ability to withstand low oxygen (hypoxia tolerance) is a polygenic and mechanistically
conserved trait that has important implications for both human health and evolution …