[HTML][HTML] Immune drivers of physiological and pathological pain

A Jain, S Hakim, CJ Woolf - Journal of Experimental Medicine, 2024 - rupress.org
Physiological pain serves as a warning of exposure to danger and prompts us to withdraw
from noxious stimuli to prevent tissue damage. Pain can also alert us of an infection or organ …

[HTML][HTML] Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury

S Osorio-Valencia, B Zhou - Biomedicines, 2024 - mdpi.com
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
present life-threatening conditions characterized by inflammation and endothelial injury …

Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease

JK Sterling, A Rajesh, S Droho, J Gong, AL Wang… - The Journal of Clinical …, 2024 - jci.org
The blood-retina barrier (BRB), which is disrupted in diabetic retinopathy (DR) and uveitis, is
an important anatomical characteristic of the retina, regulating nutrient, waste, water, protein …

Gut microbiota promotes pain chronicity in Myosin1A deficient male mice

A Reynders, ZA Jhumka, S Gaillard, A Mantilleri… - Brain, Behavior, and …, 2024 - Elsevier
Chronic pain is a heavily debilitating condition and a huge socio-economic burden, with no
efficient treatment. Over the past decade, the gut microbiota has emerged as an important …

Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage

T Geraghty, S Ishihara, AM Obeidat, NS Adamczyk… - bioRxiv, 2024 - biorxiv.org
Background: Osteoarthritis (OA) is a painful degenerative joint disease and a leading source
of years lived with disability globally due to inadequate treatment options. Neuroimmune …

Roles of Macrophages and Endothelial Cells and Their Crosstalk in Acute Lung Injury. Biomedicines 2024, 12, 632

S Osorio-Valencia, B Zhou - 2024 - europepmc.org
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS),
present life-threatening conditions characterized by inflammation and endothelial injury …

Analgesic candidate adenosine A3 receptors are expressed by perineuronal peripheral macrophages in human dorsal root ganglion and spinal cord microglia

MR Sapio, ES Staedtler, DM King, D Maric… - Pain, 2022 - journals.lww.com
Adenosine receptors are a family of purinergic G protein–coupled receptors that are widely
distributed in bodily organs and in the peripheral and central nervous systems. Recently …