A model for RAS mutation patterns in cancers: finding the sweet spot

S Li, A Balmain, CM Counter - Nature Reviews Cancer, 2018 - nature.com
The three RAS genes—HRAS, NRAS and KRAS—are collectively mutated in one-third of
human cancers, where they act as prototypic oncogenes. Interestingly, there are rather …

[HTML][HTML] Targeting KRAS in non-small-cell lung cancer: recent progress and new approaches

M Reck, DP Carbone, M Garassino, F Barlesi - Annals of Oncology, 2021 - Elsevier
Rat sarcoma (RAS) is the most frequently mutated oncogene in human cancer, with Kirsten
rat sarcoma (KRAS) being the most commonly mutated RAS isoform. Overall, KRAS …

[HTML][HTML] Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C

R Yaeger, J Weiss, MS Pelster, AI Spira… - … England Journal of …, 2023 - Mass Medical Soc
Background Adagrasib, an oral small-molecule inhibitor of mutant KRAS G12C protein, has
shown clinical activity in pretreated patients with several tumor types, including colorectal …

Defining the KRAS-and ERK-dependent transcriptome in KRAS-mutant cancers

JA Klomp, JE Klomp, CA Stalnecker, KL Bryant… - Science, 2024 - science.org
How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …

Protein degradation: expanding the toolbox to restrain cancer drug resistance

H Ming, B Li, J Jiang, S Qin, EC Nice, W He… - Journal of hematology & …, 2023 - Springer
Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

[HTML][HTML] The functions and regulation of Smurfs in cancers

L Fu, CP Cui, X Zhang, L Zhang - Seminars in cancer biology, 2020 - Elsevier
Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin
ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF …

Post-translational modification of RAS proteins

SL Campbell, MR Philips - Current opinion in structural biology, 2021 - Elsevier
Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS
proteins integrate signals from a wide array of receptors and initiate downstream signaling …

Smurfs in protein homeostasis, signaling, and cancer

P Koganti, G Levy-Cohen, M Blank - Frontiers in oncology, 2018 - frontiersin.org
Protein ubiquitination is an evolutionary conserved highly-orchestrated enzymatic cascade
essential for normal cellular functions and homeostasis maintenance. This pathway relies on …

SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation

W Zhang, J Dai, G Hou, H Liu, S Zheng, X Wang, Q Lin… - Molecular cell, 2023 - cell.com
Ferroptosis is a non-apoptotic form of regulated cell death. Glutathione (GSH) peroxidase 4
(GPX4) and GSH-independent ferroptosis suppressor protein 1 (FSP1) have been identified …

KRAS mutations in solid tumors: characteristics, current therapeutic strategy, and potential treatment exploration

Y Yang, H Zhang, S Huang, Q Chu - Journal of Clinical Medicine, 2023 - mdpi.com
Kristen rat sarcoma (KRAS) gene is one of the most common mutated oncogenes in solid
tumors. Yet, KRAS inhibitors did not follow suit with the development of targeted therapy, for …