Labeling of nucleic acids is required for many studies aiming to elucidate their functions and
dynamics in vitro and in cells. Out of the numerous labeling concepts that have been …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

The capability to screen a range of proteins at the single-molecule level with enhanced
selectivity in biological fluids has been in part a driving force in developing future diagnostic …

Solid-state nanopores are powerful tools for reading the three-dimensional shape of
molecules, allowing for the translation of molecular structure information into electric signals …

Nanofluidic structures have over the last two decades emerged as a powerful platform for
detailed analysis of DNA on the kilobase pair length scale. When DNA is confined to a …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Identifying DNA species is crucial for diagnostics. For DNA identification, single-molecule
DNA sequence mapping is an alternative to DNA sequencing toward fast point-of-care …

Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of
targets, ranging from the three major biopolymers to small molecules. Most of these MTases …

Nanopore sensors show great potential for rapid, single-molecule determination of DNA
sequence information. Here, we develop an ionic current-based method for determining the …

Nucleic acids are important biomarkers for disease detection, monitoring, and treatment.
Advances in technologies for nucleic acid analysis have enabled discovery and clinical …