Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

There is persuasive epidemiological and experimental evidence that dietary phytochemicals
have anticancer activity. Capsaicin is a bioactive phytochemical abundant in red and chili …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Extracellular vesicles (EVs) are membrane vesicles released by both eukaryotic and
prokaryotic cells; they not only serve physiological functions, such as disposal of cellular …

Reactive oxygen species (ROS) promote carcinogenesis by inducing genetic mutations,
activating oncogenes, and raising oxidative stress, which all influence cell proliferation …

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …

Pain results from the complex processing of neural signals at different levels of the central
nervous system, with each signal potentially offering multiple opportunities for …

Nanomedicine have shown success in cancer therapy, but the pharmacological actions of
most nanomedicine are often nonspecific to cancer cells because of utilization of the …

Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …