[HTML][HTML] Zoonosis and zooanthroponosis of emerging respiratory viruses

AM Khalil, L Martinez-Sobrido… - Frontiers in Cellular and …, 2024 - frontiersin.org
Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses.
All human pandemics have been caused by the members of two major virus families …

[HTML][HTML] Predictive evolutionary modelling for influenza virus by site-based dynamics of mutations

J Lou, W Liang, L Cao, I Hu, S Zhao, Z Chen… - Nature …, 2024 - nature.com
Influenza virus continuously evolves to escape human adaptive immunity and generates
seasonal epidemics. Therefore, influenza vaccine strains need to be updated annually for …

[HTML][HTML] Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin

R Lei, W Liang, WO Ouyang… - Nature …, 2024 - nature.com
The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major
antigenic sites and constantly evolves. In this study, we observe that mutations G186D and …

Hemagglutinin destabilization in H3N2 vaccine reference viruses skews antigenicity and prevents airborne transmission in ferrets

M Hu, C Kackos, B Banoth, CR Ojha, JC Jones… - Science …, 2023 - science.org
During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes
membrane fusion after endosomal acid activation. To improve vaccine efficiency and …

[HTML][HTML] Seasonal antigenic prediction of influenza A H3N2 using machine learning

SAW Shah, DP Palomar, I Barr, LLM Poon… - Nature …, 2024 - nature.com
Antigenic characterization of circulating influenza A virus (IAV) isolates is routinely assessed
by using the hemagglutination inhibition (HI) assays for surveillance purposes. It is also …

Neutralizing antibody responses against contemporary and future influenza A (H3N2) viruses in paradoxical clades elicited by repeated and single vaccinations

T Zhang, Y Han, W Huang, H Wei… - Journal of Medical …, 2024 - Wiley Online Library
As one of the most effective measures to prevent seasonal influenza viruses, annual
influenza vaccination is globally recommended. Nevertheless, evidence regarding the …

Lack of neutralizing antibodies against the current circulating influenza viruses during the Omicron outbreak in Hong Kong

W Liang, H Lv, C Chen, Y Sun, DS Hui, CK Pun Mok - bioRxiv, 2023 - biorxiv.org
We report the seroprevalence to the circulating influenza A H1N1 and H3N2 viruses from
plasma samples collected from 479 adults between 2021 and 2022. Our results show that …

[PDF][PDF] Influenza A Virus: From Infection to Prevention. Long-term Effects of an Early Life IAV Infection in vivo and Optimization of the Live Attenuated Influenza A …

JP PEREIRA BONIFACIO LOPES - scholar.archive.org
Influenza A virus (IAV) is one of the major causative agents of acute respiratory infections in
humans. Influenza disease causes up to 650,000 deaths every year with its burden highest …

[PDF][PDF] Influenza A Virus: From Infection to Prevention. Long-term Effects of an Early Life IAV Infection in vivo and Optimization of the Live Attenuated Influenza A …

JPPB LOPES - access.archive-ouverte.unige.ch
Influenza A virus (IAV) is one of the major causative agents of acute respiratory infections in
humans. Influenza disease causes up to 650,000 deaths every year with its burden highest …

Antigenic Effects of Influenza A (H3n2) Virus Egg-Adaptation Substitutions are Influenced by Evolution Associated Substitutions

AJ Hadiprodjo, YY Tseng, L Carolan… - Available at SSRN … - papers.ssrn.com
Influenza vaccine viruses are predominantly grown in embryonated hens-eggs. A (H3N2)
viruses commonly adapt to growth in eggs by substituting hemagglutinin positions G186V or …