Advances in development of exosomes for ophthalmic therapeutics

Y Tian, T Zhang, J Li, Y Tao - Advanced Drug Delivery Reviews, 2023 - Elsevier
Exosomes contain multiple bioactive molecules and maintain the connection between cells.
Recent advances in exosome-based therapeutics have witnessed unprecedented …

From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma

D Križaj, DA Ryskamp, N Tian, G Tezel… - Current eye …, 2014 - Taylor & Francis
Purpose of the study: Many blinding diseases of the inner retina are associated with
degeneration and loss of retinal ganglion cells (RGCs). Recent evidence implicates several …

Retinal explant culture: a platform to investigate human neuroretina

A Murali, CA RamloganSteel… - Clinical & …, 2019 - Wiley Online Library
The retina is the tissue responsible for light detection, in which retinal neurons convert light
energy into electrical signals to be transported towards the visual cortex. Damage of retinal …

[HTML][HTML] Hybrid three-dimensional (3D) bioprinting of retina equivalent for ocular research

P Shi, TYS Edgar, WY Yeong… - International Journal of …, 2017 - ncbi.nlm.nih.gov
In this article, a hybrid retina construct was created via three-dimensional (3D) bioprinting
technology. The construct was composed of a PCL ultrathin membrane, ARPE-19 cell …

Optic nerve as a source of activated retinal microglia post-injury

ND Heuss, MJ Pierson, H Roehrich… - Acta neuropathologica …, 2018 - Springer
Using mice expressing green fluorescent protein (GFP) from a transgenic CD11c promoter
we found that a controlled optic nerve crush (ONC) injury attracted GFP hi retinal myeloid …

[HTML][HTML] Hyaluronan-cholesterol nanogels for the enhancement of the ocular delivery of therapeutics

N Zoratto, L Forcina, R Matassa, L Mosca, G Familiari… - Pharmaceutics, 2021 - mdpi.com
The anatomy and physiology of the eye strongly limit the bioavailability of locally
administered drugs. The entrapment of therapeutics into nanocarriers represents an …

Visual outcomes after blunt ocular trauma

RJ Blanch, PA Good, P Shah, JRB Bishop, A Logan… - Ophthalmology, 2013 - Elsevier
Objective To describe the prognosis and retinal location in patients presenting with acute
traumatic maculopathy and extramacular retinal injuries. Design Retrospective …

[HTML][HTML] Exploiting mTOR signaling: a novel translatable treatment strategy for traumatic optic neuropathy?

PJ Morgan-Warren, M Berry, Z Ahmed… - … & visual science, 2013 - arvojournals.org
Retinal ganglion cell (RGC) death and a failure of axon regeneration contribute to the
profound visual loss experienced by patients after traumatic optic neuropathy (TON), for …

The choroidal rupture: current concepts and insights

M Lupidi, A Muzi, G Castellucci, G Kalra… - Survey of …, 2021 - Elsevier
Choroidal rupture is a posterior segment affliction following a traumatic event that results in a
break in the retinal pigment epithelium, Bruch membrane, and the underlying …

Epigallocatechin 3-gallate has a neuroprotective effect in retinas of rabbits with ischemia/reperfusion through the activation of Nrf2/HO-1

J Rivera-Pérez, M Martínez-Rosas… - International Journal of …, 2020 - mdpi.com
Retinal ischemia-reperfusion (rI/R) generates an oxidative condition causing the death of
neuronal cells. Epigallocatechin 3-gallate (EGCG) has antioxidant and anti-inflammatory …