Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …

The KMT2A (formerly MLL) encodes the histone lysine-specific N-methyltransferase 2A and
is mapped on chromosome 11q23. KMT2A is a frequent target for recurrent translocations in …

Abstract KMT2A rearranged (KMT2A r) acute lymphoblastic leukaemia (ALL) is a high-risk
genomic subtype, with long-term survival rates of less than 60% across all age groups …

Central nervous system (CNS) involvement in pediatric B-cell precursor acute lymphoblastic
leukemia (BCP-ALL) is rarely detected at initial presentation. 1 Nevertheless, CNS relapse …

Balanced rearrangements involving the KMT2A gene (KMT2A r) are recurrent genetic
abnormalities in acute myeloid leukemia (AML), but there is lack of consensus regarding the …

Background Alterations of FLT3 are among the most common driver events in acute
leukaemia with important clinical implications, since it allows patient classification into …

Clinical management and risk stratification of B-lymphoblastic leukemia/lymphoma (B-
ALL/LBL) depend largely on identification of chromosomal abnormalities obtained using …

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are one of the most common
observed genetic events in lung adenocarcinoma. The present study aimed to characterize …

Within the various subtypes of ALL, patients with a BCR-ABL-positive background as well as
with a genetic change in the KMT2A gene have by far the worst survival probabilities …

Rearrangements of the MLLT10 gene occur in acute myeloid leukemia (AML) and acute
lymphoblastic leukemia (ALL), most commonly T‐lineage ALL (T‐ALL), in patients of all …