The biological function of the cellular prion protein: an update
MA Wulf, A Senatore, A Aguzzi - BMC biology, 2017 - Springer
The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …
Prions
SB Prusiner - Proceedings of the National Academy of …, 1998 - National Acad Sciences
Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …
Neurodegenerative diseases: expanding the prion concept
LC Walker, M Jucker - Annual review of neuroscience, 2015 - annualreviews.org
The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …
A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
There has been an explosion in the number of papers discussing the hypothesis
of'pathogenic spread'in neurodegenerative disease—the idea that abnormal forms of …
of'pathogenic spread'in neurodegenerative disease—the idea that abnormal forms of …
Molecular biology of prion diseases
SB Prusiner - Science, 1991 - science.org
Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …
Scrapie prion protein contains a phosphatidylinositol glycolipid
N Stahl, DR Borchelt, K Hsiao, SB Prusiner - Cell, 1987 - cell.com
The scrapie (PrPsC) and cellular (PrPc) prion proteins are encoded by the same gene, and
their different properties am thought to arise from posttranslational modifications. We have …
their different properties am thought to arise from posttranslational modifications. We have …
Prions: protein aggregation and infectious diseases
A Aguzzi, AM Calella - Physiological reviews, 2009 - journals.physiology.org
Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …
diseases that affect humans and a large variety of animals. The infectious agent responsible …
Prion protein biology
SB Prusiner, MR Scott, SJ DeArmond, FE Cohen - cell, 1998 - cell.com
Prion Protein Biology: Cell Skip to Main Content Advertisement Cell This journal offers authors
two options (open access or subscription) to publish research Submit Log in Register Log in …
two options (open access or subscription) to publish research Submit Log in Register Log in …
Sporadic and familial CJD: classification and characterisation
Prion diseases are unique transmissible neurodegenerative diseases that have diverse
phenotypes and can be familial, sporadic, or acquired by infection. Recent findings indicate …
phenotypes and can be familial, sporadic, or acquired by infection. Recent findings indicate …
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
K Basler, B Oesch, M Scott, D Westaway, M Wälchli… - Cell, 1986 - cell.com
PrP 27-30 is the major protein in purified preparations of scrapie agent. An almost complete
PrP cDNA was used to select PrP-related genomic clones from normal hamster DNA. The …
PrP cDNA was used to select PrP-related genomic clones from normal hamster DNA. The …