The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

Prions are unprecedented infectious pathogens that cause a group of invariably fatal
neurodegenerative diseases by an entirely novel mechanism. Prion diseases may present …

The prion paradigm has emerged as a unifying molecular principle for the pathogenesis of
many age-related neurodegenerative diseases. This paradigm holds that a fundamental …

There has been an explosion in the number of papers discussing the hypothesis
of'pathogenic spread'in neurodegenerative disease—the idea that abnormal forms of …

Prions cause transmissible and genetic neurodegenerative diseases, including scrapie and
bovine spongiform encephalopathy of animals and Creutzfeldt-Jakob and Gerstmann …

The scrapie (PrPsC) and cellular (PrPc) prion proteins are encoded by the same gene, and
their different properties am thought to arise from posttranslational modifications. We have …

Transmissible spongiform encephalopathies (TSEs) are inevitably lethal neurodegenerative
diseases that affect humans and a large variety of animals. The infectious agent responsible …

Prion Protein Biology: Cell Skip to Main Content Advertisement Cell This journal offers authors
two options (open access or subscription) to publish research Submit Log in Register Log in …

Prion diseases are unique transmissible neurodegenerative diseases that have diverse
phenotypes and can be familial, sporadic, or acquired by infection. Recent findings indicate …

PrP 27-30 is the major protein in purified preparations of scrapie agent. An almost complete
PrP cDNA was used to select PrP-related genomic clones from normal hamster DNA. The …