The relevance of protein stability for biological function and molecular evolution is widely
recognized. Protein stability, however, comes in two flavours: thermodynamic stability, which …

This review provides an exposition to the important problems of (i) structure prediction in
protein folding and (ii) de novo protein design. The recent advances in protein folding are …

An outstanding challenge in the field of molecular biology has been to understand the
process by which proteins fold into their characteristic three-dimensional structures. Here …

The millisecond time scale needed for molecular dynamics simulations to approach the
quantitative study of protein folding is not yet routine. One approach to extend the simulation …

Protein Folding Kinetics-Biophysical Methods (2nd Edition) gives a deep insight into the
principles and concepts of the kinetic and structural resolution of fast chemical and …

Correlated motions of proteins are critical to function, but these features are difficult to
resolve using traditional structure determination techniques. Time-resolved X-ray methods …

Here, we describe the folding/unfolding kinetics of α3D, a small designed three-helix bundle.
Both IR temperature jump and ultrafast fluorescence mixing methods reveal a single …

To illuminate the evolutionary pressure acting on the folding free energy landscapes of
naturally occurring proteins, we have systematically characterized the folding free energy …

Fast-folding proteins have been a major focus of computational and experimental study
because they are accessible to both techniques: they are small and fast enough to be …

Computational protein design continues to experience a variety of methodological
advances. Several improvements have been suggested for the objective functions used to …