The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

To better understand the gene regulatory mechanisms that program developmental
processes, we carried out simultaneous genome-wide measurements of mRNA, translation …

While the field of epigenetics is increasingly recognized to contribute to the emergence of
phenotypes in mammalian research models across different developmental and …

Background Early embryonic developmental programs are guided by the coordinated
interplay between maternally inherited and zygotically manufactured RNAs and proteins …

Background The start and end sites of messenger RNAs (TSSs and TESs) are highly
regulated, often in a cell-type-specific manner. Yet the contribution of transcript diversity in …

Over the past decade, high‐throughput studies have identified many novel transcripts. While
their existence is undisputed, their coding potential and functionality have remained …

Vertebrate evolution was accompanied by two rounds of whole-genome duplication
followed by functional divergence in terms of regulatory circuits and gene expression …

Cell differentiation programs require dynamic regulation of gene expression. During meiotic
prophase in Saccharomyces cerevisiae, expression of the kinetochore complex subunit …

Sex-specific splicing is an essential process that regulates sex determination and drives
sexual dimorphism. Yet, how early in development widespread sex-specific transcript …