The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Pathological implication of protein post-translational modifications in cancer

S Pan, R Chen - Molecular aspects of medicine, 2022 - Elsevier
Protein post-translational modifications (PTMs) profoundly influence protein functions and
play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and …

Glycosylation in cancer: mechanisms and clinical implications

SS Pinho, CA Reis - Nature Reviews Cancer, 2015 - nature.com
Despite recent progress in understanding the cancer genome, there is still a relative delay in
understanding the full aspects of the glycome and glycoproteome of cancer. Glycobiology …

Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies

B Greco, V Malacarne, F De Girardi, GM Scotti… - Science translational …, 2022 - science.org
Immunotherapy with chimeric antigen receptor (CAR)–engineered T cells showed
exceptional successes in patients with refractory B cell malignancies. However, first-in …

Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Altered cell adhesion and glycosylation promote cancer immune suppression and metastasis

H Läubli, L Borsig - Frontiers in immunology, 2019 - frontiersin.org
Cell-cell interactions and cell adhesion are key mediators of cancer progression and
facilitate hallmarks of cancer including immune evasion and metastatic dissemination. Many …

Glycans and glycoproteins as specific biomarkers for cancer

MJ Kailemia, D Park, CB Lebrilla - Analytical and bioanalytical chemistry, 2017 - Springer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Cell surface protein glycosylation in cancer

MN Christiansen, J Chik, L Lee, M Anugraham… - …, 2014 - Wiley Online Library
Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

The galectin lattice at a glance

IR Nabi, J Shankar, JW Dennis - Journal of cell science, 2015 - journals.biologists.com
Galectins are a family of widely expressed β-galactoside-binding lectins in metazoans. The
15 mammalian galectins have either one or two conserved carbohydrate recognition …

Chemical synthesis of glycosaminoglycans

M Mende, C Bednarek, M Wawryszyn, P Sauter… - Chemical …, 2016 - ACS Publications
Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …