Nearly one in six people worldwide suffer from disorders of the central nervous system
(CNS). There is an urgent need for effective strategies to improve the success rates in CNS …

Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The blood brain barrier (BBB) and blood tumour barrier (BTB) remain a major roadblock for
delivering therapies to treat brain cancer. Amongst brain cancers, glioblastoma (GBM) is …

Medulloblastoma (MB) is a major pediatric malignant brain tumor that arises in the
cerebellum. MB tumors exhibit highly heterogeneous driven by diverse genetic alterations …

Gemcitabine (GEM) chemotherapy, as the first-line regimen for pancreatic cancer, tends to
induce drug resistance, which ultimately worsens the prognosis of patients with pancreatic …

The sensitive analysis of microRNAs (miRNAs) in cerebrospinal fluid (CSF) holds promise
for the minimally invasive early diagnosis of brain cancers such as pediatric …

We previously reported evidence that oxidative stress during aging leads to adverse protein
profile changes of brain cortical microvessels (MVs: end arterioles, capillaries, and venules) …

Scientists are looking for new therapies to cope with the rise in cancer worldwide. Since
cancer cells overexpress peptide receptors and owing to small size, easy uptake by tumor …

Bacteriophages infect and replicate within bacteria and play a key role in the environment,
particularly in microbial ecosystems and bacterial population dynamics. The increasing …