The development of miniaturized imaging equipment and reporter probes has improved our
ability to study animal models of disease, such as transgenic and knockout mice. These …

The study of chemical exchange processes is one of the oldest and still most vigorously
investigated topics in NMR spectroscopy. The effects of chemical exchange on the NMR …

In this work we demonstrate that specific MR image contrast can be produced in the water
signal that reflects endogenous cellular protein and peptide content in intracranial rat 9L …

Dynamic contrast enhanced MRI (DCE-MRI) enables the quantitative assessment of tumor
status and has found application in both pre-clinical tumor models as well as clinical …

Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) is performed after the
administration of intravenous contrast medium to noninvasively access tumor vascular …

Molecular-targeted agents are increasingly used for the treatment of cancer. However, the
attrition rate for drugs that enter early clinical trials is higher than for other branches of …

Amide proton transfer (APT) imaging is a technique in which the nuclear magnetization of
water‐exchangeable amide protons of endogenous mobile proteins and peptides in tissue …

▪ Abstract Magnetic resonance spectroscopy (MRS) has been used for more than two
decades to interrogate metabolite distributions in living cells and tissues. Techniques have …

Strict coordination of proliferation and programmed cell death (apoptosis) is essential for
normal physiology. An imbalance in these two opposing processes results in various …

Among the newly described tools that enable analyses of cellular and molecular events in
living animals, in vivo bioluminescence imaging (BLI) offers important opportunities for …