Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

The arachidonic acid cascade is arguably the most widely known biologic regulatory
pathway. Decades after the seminal discoveries involving its cyclooxygenase and …

Cancer therapy, including immunotherapy, is inherently limited by chronic inflammation-
induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the …

Cytochrome P450 (CYP) enzymes are frequently referred to as the third pathway for the
metabolism of arachidonic acid. While it is true that these enzymes generate arachidonic …

Cancer therapy reduces tumor burden via tumor cell death (“debris”), which can accelerate
tumor progression via the failure of inflammation resolution. Thus, there is an urgent need to …

Background/Aim: Cytochrome P450 epoxygenase is a major enzyme involved in the
metabolism of ω-3 polyunsaturated fatty acids (PUFAs) to produce biologically active ω-3 …

Over the last two decades polypharmacology has emerged as a new paradigm in drug
discovery, even though developing drugs with high potency and selectivity toward a single …

Angiogenesis and inflammation are hallmarks of cancer. Arachidonic acid and other
polyunsaturated fatty acids (PUFAs) are primarily metabolized by three distinct enzymatic …

Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are
made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function …

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating disease
with the 5‐year survival rate less than 6%. In this study, we investigated if inhibiting protein …