ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

The concept of insulin resistance has been around since a few decades after the discovery
of insulin itself. To allude to the classic Charles Dicken's novel published 62 years before the …

Alzheimer's disease (AD) is caused by a complex interaction between genetic and
environmental factors. However, how the role of peripheral organ changes in response to …

Background Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4
allele are associated with an increased risk of Alzheimer's disease (AD). Although the …

Background The APOE ε4-promoted risk of Alzheimer's disease (AD) is lower in
Black/African-Americans (B/AAs), compared to non-Hispanic whites (NHWs). Previous …

C-reactive protein (CRP) impacts apolipoprotein E4 (ApoE4) allele to increase Alzheimer's
disease (AD) risk. However, it is unclear how the ApoE protein and its binding to LRP1 are …

INTRODUCTION The most significant genetic risk factor for late‐onset Alzheimer's disease
(AD) is APOE4, with evidence for gain‐and loss‐of‐function mechanisms. A clinical need …

Background Alzheimer's disease (AD) is foremost characterized by β-amyloid (Aβ)-
extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but …

Alzheimer's disease (AD) is the most common neurodegenerative disease and is
characterized by progressive memory loss and learning impairment. Dysfunction of amyloid …

Plasma apolipoprotein E levels were previously associated with the risk of developing
Alzheimer's disease (AD), levels of cerebrospinal fluid AD biomarkers, cognition and …