Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development

CE Murry, G Keller - Cell, 2008 - cell.com
The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Stem-cell-based therapy and lessons from the heart

R Passier, LW van Laake, CL Mummery - Nature, 2008 - nature.com
The potential usefulness of human embryonic stem cells for therapy derives from their ability
to form any cell in the body. This potential has been used to justify intensive research …

Efficient differentiation of human pluripotent stem cells to endothelial progenitors via small-molecule activation of WNT signaling

X Lian, X Bao, A Al-Ahmad, J Liu, Y Wu, W Dong… - Stem cell reports, 2014 - cell.com
Human pluripotent stem cell (hPSC)-derived endothelial cells and their progenitors may
provide the means for vascularization of tissue-engineered constructs and can serve as …

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs

G Lee, EP Papapetrou, H Kim, SM Chambers… - nature, 2009 - nature.com
The isolation of human induced pluripotent stem cells (iPSCs),, offers a new strategy for
modelling human disease. Recent studies have reported the derivation and differentiation of …

Scalable generation of universal platelets from human induced pluripotent stem cells

Q Feng, N Shabrani, JN Thon, H Huo, A Thiel… - Stem cell reports, 2014 - cell.com
Human induced pluripotent stem cells (iPSCs) provide a potentially replenishable source for
the production of transfusable platelets. Here, we describe a method to generate …

Expansion and maintenance of human embryonic stem cell–derived endothelial cells by TGFβ inhibition is Id1 dependent

D James, H Nam, M Seandel, D Nolan, T Janovitz… - Nature …, 2010 - nature.com
Previous efforts to differentiate human embryonic stem cells (hESCs) into endothelial cells
have not achieved sustained expansion and stability of vascular cells. To define …

Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence

Q Feng, SJ Lu, I Klimanskaya, I Gomes, D Kim… - Stem …, 2010 - academic.oup.com
Human induced pluripotent stem cells (hiPSC) have been shown to differentiate into a
variety of replacement cell types. Detailed evaluation and comparison with their human …

A protocol describing the use of a recombinant protein-based, animal product-free medium (APEL) for human embryonic stem cell differentiation as spin embryoid …

ES Ng, R Davis, EG Stanley, AG Elefanty - Nature protocols, 2008 - nature.com
In order to promote the uniform and reproducible differentiation of human embryonic stem
cells (HESCs) in response to exogenously added growth factors, we have developed a …

Controlled differentiation of stem cells

NS Hwang, S Varghese, J Elisseeff - Advanced drug delivery reviews, 2008 - Elsevier
The extracellular microenvironment plays a significant role in controlling cellular behavior.
Identification of appropriate biomaterials that support cellular attachment, proliferation and …

ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells

R Morita, M Suzuki, H Kasahara… - Proceedings of the …, 2015 - National Acad Sciences
Transplantation of endothelial cells (ECs) is a promising therapeutic approach for ischemic
disorders. In addition, the generation of ECs has become increasingly important for …