The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron
and the skeletal muscle fiber and is crucial for conversion of electrical impulses originating …

Duchenne muscular dystrophy (DMD) is a progressive disease caused by the loss of
function of the protein dystrophin. This protein contributes to the stabilisation of striated cells …

Syncytial skeletal muscle cells contain hundreds of nuclei in a shared cytoplasm. We
investigated nuclear heterogeneity and transcriptional dynamics in the uninjured and …

Our previous studies have shown that extracellular vesicles from skin-derived precursor
Schwann cells (SKP-SC-EVs) promote neurite outgrowth of sensory and motor neurons in …

Dysregulation of mTOR complex 1 (mTORC1) activity drives neuromuscular junction (NMJ)
structural instability during aging; however, downstream targets mediating this effect have …

The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a
motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into …

Rapid 3D imaging of entire organs and organisms at cellular resolution is a recurring
challenge in life science. Here we report on a computational light-sheet microscopy able to …

Volumetric muscle loss (VML) is the traumatic loss of muscle tissue that results in long-term
functional impairments. Despite the loss of myofibers, there remains an unexplained …

The skeletal muscle Ca2+ release channel, also known as ryanodine receptor type 1
(RyR1), is the largest ion channel protein known and is crucial for effective skeletal muscle …

Duchenne muscular dystrophy (DMD) is an X‐linked neuromuscular disease caused by a
deficiency in dystrophin–a structural protein which stabilises muscle during contraction …