Interactions between immune and malignant cells have been known to have clinical
relevance for decades. The potential for immune control is now being therapeutically …

Primary liver cancer (PLC) is one of the most common malignancies in China, where it ranks
second in mortality and fifth in morbidity. Currently, liver transplantation, hepatic tumor …

Immune checkpoint blockade has become a promising therapeutic approach to reverse
immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain …

ABSTRACT Background and Aims: As the predominant lymphocyte subset in the liver,
natural killer (NK) cells have been shown to be highly associated with the outcomes of …

As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded
by TP 53) plays a central role in response to various cellular stresses. A variety of biological …

Tumor-infiltrating immune cells are highly relevant for prognosis and identification of
immunotherapy targets in hepatocellular carcinoma (HCC). The recently developed …

Objectives Immunoscore evaluates the density of CD3+ and CD8+ T cells in both the tumor
core and invasive margin. Pretreatment prediction of immunoscore in hepatocellular cancer …

Abstract The American Joint Committee on Cancer/Union Internationale Contre le Cancer
(AJCC/UICC) tumor, nodes, metastasis (TNM) classification system based on tumor features …

Background Hepatocellular carcinoma (HCC) is a highly lethal cancer and the second
leading cause of cancer-related deaths worldwide. As demonstrated in other solid …

Background: In patients with hepatocellular carcinoma (HCC), the prognostic role of tumor-
infiltrating lymphocytes (TILs) for survival is still controversial. A meta-analysis was …