Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments
Ketamine has emerged as a transformative and mechanistically novel pharmacotherapy for
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
depression. Its rapid onset of action, efficacy for treatment-resistant symptoms, and …
Clinical and therapeutic significance of genetic variation in the GRIN gene family encoding NMDARs
Considerable genetic variation of N-methyl-d-aspartate receptors (NMDARs) has recently
become apparent, with many hundreds of de novo variants identified through widely …
become apparent, with many hundreds of de novo variants identified through widely …
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research
S Lv, K Yao, Y Zhang, S Zhu - Neuropharmacology, 2023 - Elsevier
Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
Tonic activation of GluN2C/GluN2D-containing NMDA receptors by ambient glutamate facilitates cortical interneuron maturation
E Hanson, M Armbruster, LA Lau… - Journal of …, 2019 - Soc Neuroscience
Developing cortical GABAergic interneurons rely on genetic programs, neuronal activity, and
environmental cues to construct inhibitory circuits during early postnatal development …
environmental cues to construct inhibitory circuits during early postnatal development …
Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research
MR Dauvermann, G Lee… - British journal of …, 2017 - Wiley Online Library
The pharmacological modulation of glutamatergic neurotransmission to improve cognitive
function has been a focus of intensive research, particularly in relation to the cognitive …
function has been a focus of intensive research, particularly in relation to the cognitive …
N-Methyl-D-Aspartate (NMDA) receptor modulators: a patent review (2015-present)
Introduction–The NMDA receptor is implicated in various diseases including
neurodegenerative, neurodevelopmental and mood disorders. However, only a limited …
neurodegenerative, neurodevelopmental and mood disorders. However, only a limited …
N‐methyl‐d‐aspartate receptors: Structure, function, and role in organophosphorus compound poisoning
D Kolić, Z Kovarik - Biofactors, 2024 - Wiley Online Library
Acute organophosphorus compound (OP) poisoning induces symptoms of the cholinergic
crises with the occurrence of severe epileptic seizures. Seizures are induced by …
crises with the occurrence of severe epileptic seizures. Seizures are induced by …
Astrocyte GluN2C NMDA receptors control basal synaptic strengths of hippocampal CA1 pyramidal neurons in the stratum radiatum
PH Chipman, CCA Fung, AP Fernandez, A Sawant… - Elife, 2021 - elifesciences.org
Experience-dependent plasticity is a key feature of brain synapses for which neuronal N-
Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit …
Methyl-D-Aspartate receptors (NMDARs) play a major role, from developmental circuit …
Region-specific expression of NMDA receptor GluN2C subunit in parvalbumin-positive neurons and astrocytes: analysis of GluN2C expression using a novel reporter …
Hypofunction of NMDA receptors in parvalbumin (PV)-positive interneurons has been
proposed as a potential mechanism for cortical abnormalities and symptoms in …
proposed as a potential mechanism for cortical abnormalities and symptoms in …
Histamine H1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice
Negative symptoms in schizophrenia strongly contribute to poor functional outcomes,
however its pathogenesis is still unclear. Here, we found that histamine H1 receptor (H1R) …
however its pathogenesis is still unclear. Here, we found that histamine H1 receptor (H1R) …