Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and
economic loss in many parts of the world, despite current control efforts, and new …

In the human malaria vector Anopheles gambiae, the gene doublesex (Agdsx) encodes two
alternatively spliced transcripts, dsx-female (AgdsxF) and dsx-male (AgdsxM), that control …

Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-
control methods, several novel mosquito vector-based control strategies have been …

Genetic engineering technologies can be used both to create transgenic mosquitoes
carrying antipathogen effector genes targeting human malaria parasites and to generate …

Gene drive systems that enable super-Mendelian inheritance of a transgene have the
potential to modify insect populations over a timeframe of a few years. We describe CRISPR …

Gene drives have enormous potential for the control of insect populations of medical and
agricultural relevance. By preferentially biasing their own inheritance, gene drives can …

Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …

Plasmodium relies on numerous agonists during its journey through the mosquito vector,
and these agonists represent potent targets for transmission-blocking by either inhibiting or …

Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect
reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses …

Transmission of malaria parasites occurs when a female Anopheles mosquito feeds on an
infected host to acquire nutrients for egg development. How parasites are affected by …