In recent years, much interest has been devoted to defining the role of the IGF system in the
nervous system. The ubiquitous IGFs, their cell membrane receptors, and their carrier …

The effects of oxidative stress within post mitotic cells such as neurones may be cumulative,
and injury by free radical species is a major potential cause of the age‐related deterioration …

Specific neuronal subtypes, especially motoneurons (MNs), derived from human stem cells
provide a significant therapeutic potential for spinal cord diseases, such as amyotrophic …

Progesterone (PROG) provides neuroprotection to the injured central and peripheral
nervous system. These effects may be due to regulation of myelin synthesis in glial cells and …

OBJECTIVE: Previous studies have revealed a loss of functioning motor units in stroke
patients. However, it remained unclear whether the motor units are affected randomly or in …

This review discusses the roles of the transforming growth factor-betas (TGF-βs) as part of a
complex network that regulates the development and maintenance of the neuromuscular …

Amongst the many soluble extracellular factors stimulating intracellular signal transduction
pathways and driving cellular processes such as proliferation, differentiation and survival …

Many neurotrophic factors have been shown to enhance survival of embryonic motor
neurons or affect their response to injury. Few studies have investigated the potential effects …

Pathogenic conditions involving degeneration of spinal motor neurons (MNs), such as
amyotrophic lateral sclerosis, sarcopenia, and spinal cord injury, mostly occur in individuals …

OBJECTIVES: Previous studies have revealed a selective functional loss of the large, high-
threshold motor units in the paretic muscles after lesion of the upper motor neuron. We set …