Chimeric antigen receptor T cells (CAR T cells) are engineered cells expressing a chimeric
antigen receptor (CAR) against a specific tumor antigen (TA) that allows for the identification …

Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

Tumor-associated hydrocephalus (TAH) is a common and lethal complication of brain
metastases. Although other factors beyond mechanical obstructions have been suggested …

Abstract Background Within PF-EPN-A, 1q gain is a marker of poor prognosis, however, it is
unclear if within PF-EPN-A additional cytogenetic events exist which can refine risk …

Central nervous system (CNS) tumors are the most common solid tumor in pediatrics,
accounting for approximately 25% of all childhood cancers, and the second most common …

Pediatric brain tumors (PBTs), the most common solid tumors of childhood, are a leading
cause of cancerrelated morbidity. Advancements in treatment have significantly improved …

Simple Summary Brain tumors remain the most common childhood solid tumors, accounting
for approximately 25% of all pediatric cancers. They also represent the most common cause …

Background This report documents the clinical characteristics, molecular grouping, and
outcome of young children with ependymoma treated prospectively on a clinical trial …

Chimeric Antigen Receptor (CAR) T cell therapy has recently begun to be used for solid
tumors such as glioblastoma multiforme. Many children with pediatric malignant brain …

Accurate pathologic diagnoses and molecularly informed treatment decisions for a wide
variety of cancers depend on robust clinical molecular testing that uses genomic …